Frank Little was born in 1879. Little is known about his family background but he told friends that he had "Indian blood". However, Sal Salerno argues that he had a Cherokee Indian mother and Quaker father.
Little joined the Industrial Workers of the World in 1906 and took part in the free speech campaigns in Missoula, Fresno and Spokane and was involved in organizing lumberjacks, metal miners and oil field workers into trade unions. On one occasion he was sentenced to 30 days imprisonment for reading the Declaration of Independence on a street corner.
Other members of the IWW included: William Haywood, Vincent Saint John, Daniel De Leon, Eugene V. Debs, Elizabeth Gurley Flynn, Mary 'Mother' Jones, Lucy Parsons, Hubert Harrison, Carlo Tresca, Joseph Ettor, Arturo Giovannitti, James Cannon, William Z. Foster, Eugene Dennis, Joe Haaglund Hill, Tom Mooney, Floyd B. Olson, James Larkin,